The Lipoprotein(a) molecule contributes to Atherosclerosis and Myocardial Infarction in three  ways.

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  • How common is it to have "high" Lipoprotein(a)? 20% of the population worldwide, or 1 out of 5 individuals have high Lipoprotein(a).

  • Who does elevated Lipoprotein(a) affect? It is highly heritable, so if you have a family member with high Lp(a) you may also have a higher risk.

  • What does high Lp(a) do? 1 in 14 heart attacks and 1 in 7 cases of aortic valve disease are due to Lp(a) cholesterol.

  • Why hasn't my Lp(a) level been tested? Lipoprotein(a) is not tested in your standard cholesterol panel. Instead it has been researched and treated primarily by Lipid Specialists until major advances were made over the past few years.

  • What can I do if my Lipoprotein(a) is higher than normal? Unfortunately healthy diet, excercise, and statins (the most common treatment for other types of cholesterol) have no effect on Lp(a). It is best to consult your doctor or a Lipid Specialist.


As shown in the image above, the Lipoprotein(a) molecule contributes to Atherosclerosis (fatty deposits that can clog arteries) and Myocardial Infarction (heart attack) in three  ways. First it promotes the development of fatty streaks in the arteries. This leads to the buildup of plaque along the Arterial Wall. Lastly it inhibits the body's ability to stop clots which leads to the blocked artery and thus a heart attack. One could not design a better molecule to cause coronary artery disease.

Patients with High Lipoprotein(a)

Treatment Options

PCSK9 Inhibitors

In addition to lowering blood cholesterol levels, PCSK9 inhbitors diminish Lipoprotein(a) concentrations.


lipoprotein apheresis is very efficient in decreasing Lp(a) concentrations