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As shown in the image above, the Lipoprotein(a) molecule contributes to Atherosclerosis (fatty deposits that can clog arteries) and Myocardial Infarction (heart attack) in three ways. First it promotes the development of fatty streaks in the arteries. This leads to the buildup of plaque along the Arterial Wall. Lastly it inhibits the body's ability to stop clots which leads to the blocked artery and thus a heart attack. One could not design a better molecule to cause coronary artery disease.
In addition to lowering blood cholesterol levels, PCSK9 inhbitors diminish Lipoprotein(a) concentrations.
lipoprotein apheresis is very efficient in decreasing Lp(a) concentrations