Lipoprotein(a) Center And Research InstitutE


Lipoprotein(a) or Lp(a) is a fatty particle in the blood that can lead to health problems including heart attack. In fact, 1 in 5 people have elevated lipoprotein(a) which could put them at risk. Unlike other lipoproteins such as HDL and LDL cholesterol, Lp(a) is not tested as a part of one's routine cholesterol check. Similarly, Lp(a) is not affected by changing diet, exercise, or by taking statins. This makes it particularly dangerous for athletes and those who are generally ruled out of having cholesterol or heart related illness due to their lifestyle.

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For Patients


Your health is important. If you or a family member have elevated levels of Lipoprotein(a) there are resources for information and treatment. Here you can learn more about what you can do after getting your Lp(a) level tested.

For Physicians


In an effort to raise awareness of the dangers of Lipoprotein(a) we are dedicated to informing physicians as well as patients. Here you can find information on the impact high Lp(a) can have on your patients.

For Minnesota Residents


The Lipoprotein(a) Center And Research InstitutE is based out of Minnesota, with a special interest in educating local residents (especially athletes) of the dangers of high Lp(a). Here you can find local resources and information.

Lipoprotein(a): The Common, Ugly, and Neglected Lipoprotein

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Lipoprotein(a) Molecule

Lipoprotein(a) is composed of an LDL-like particle and an additional apolipoprotein called apolipoprotein(a) [apo(a)] that is bound to apolipoprotein B (apoB) by a disulfide bridge. 


Elevated Lipoprotein(a) Effects

As shown in the image above, the Lipoprotein(a) molecule contributes to Atherosclerosis (fatty deposits that can clog arteries) and Myocardial Infarction (heart attack) in three  ways. First it promotes the development of fatty streaks in the arteries. This leads to the buildup of plaque along the Arterial Wall. Lastly it inhibits the body's ability to stop clots which leads to the blocked artery and thus a heart attack. One could not design a better molecule to cause coronary artery disease.

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